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We’ve worked with people of all ages, and there are a few aging supplements that we always explore for some of our older clients.
One type of supplement that has gained more attention in the nutrition world is designed to boost nicotinamide adenine dinucleotide (NAD) levels.
Some scientific research suggests that these supplements help with DNA repair, healthy aging, and life extension, but we were more interested in their immediate effects on energy levels.
So we teamed up with a few clients to test some of the best NAD supplements and verify their claims to determine which one is right for healthy aging.
Over a three-month period, we observed and noted changes in energy levels, cognitive function, and sleep quality.
Our Top NAD+ Supplements (September 2023)
1 - Wonderfeel® Youngr™ (Editor's Choice)
Wonderfeel provides a daily dose of 900 mg NMN (nicotinamide mononucleotide), an important dietary supplement in slowing cellular aging and supporting cellular energy metabolism.
This amount of NMN is effective for promoting cellular health, raising energy levels, and reducing sleep problems and is backed by the latest human clinical trials.
Wonderfeel nicotinamide adenine dinucleotide dietary supplement is crafted in the USA in GMP-compliant facilities to ensure maximum quality.
In addition, it contains no preservatives, is non-GMO and vegan-friendly, and is free of gluten, dairy, fish, and soy.
The clinical trials also showed increased athletic performance, making this supplement one of the best NAD supplements for the elderly indulging in sports activities.
Amount:
- 900 mg NMN
- Boosts recovery after long-working days
- It makes aerobic activities much easier
- It has an affordable price
- The 900 mg dose may be too much for certain people
Compared to Tru Niagen® and Thorne Research ResveraCel, a daily dose of Wonderfeel has a bigger impact on your focus and clarity.
2 - Tru Niagen®
As one of the most popular nicotinamide riboside supplements on the list, Tru Niagen® is one of the products that stood out in our tests due to its high potency. The specific source and type of nicotinamide were chosen based on scientific trials that showed positive results.
It contains 300 mg of nicotinamide riboside from Niagen®, a patented form of nicotinamide riboside NR that supports energy production and cellular function. It has the approval of FDA-approved scientific research as well.
With this, it claims to support cellular function and metabolism, increase cellular energy production, promote cellular repair, and defend cells against metabolic stresses in order to maintain overall health status. It applies whether your current goal is weight gain or weight loss.
Check out our full Tru Niagen review.
Amount:
- Nicotinamide Riboside : 300 mg
- Claims to help reduce metabolic stressors
- The formula was chosen based on results from human clinical trials
- Positive reviews about effects kicking in after two weeks
- Available with great subscription discounts
- The anti-aging effects may take longer to become visible
Our research and editorial team observed significant health improvements in our clients' energy metabolism and immune systems in as little as two weeks of regular NAD supplements, which makes it one of the faster-acting supplements.
This supplement also has a 150 mg version where you can take two capsules separately throughout the day to meet the recommended 300 mg daily dosage.
The only thing you might not notice immediately is the effect on the physical aging as this could take several months.
3 - Invity NAD+ Booster Energy
Invity is a brand I've personally used in my coaching practice. Their brand of NAD+ Booster Energy performs well according to the feedback I get from my clients.
A number of my clients reported feeling more energized throughout the day after using it, substantiating
What sets it apart is its convenient sachets with an exact dose of powder for cellular support and natural energy production. These have been game changers according to my clients, especially when they need a quick boost to support cellular energy during long work hours.
That makes it easy to put it in your bag and take it later in the day at work for a mental boost.
Our experience also showed that the powder mixes fast with water into a tasty and refreshing drink. The orange flavor is completely natural, and it’s not over-sweetened to mask artificial flavors.
There’s also a long list of B vitamins included, which should have a positive effect on your overall energy levels as well. Our testing did confirm that we felt more energized for longer parts of the day.
Amount:
- Nicotinamide Mononucleotide (NMN) : 150 mg
- Comes in a natural orange flavor that isn’t overpowering
- Added vitamins for boosted mental and physical energy
- The powder mixes easily with water and comes in convenient sachets
- Only available in packs of 15
4 - eSquared Nutrition Nicotinamide with Resveratrol
We thought this supplement had a clever name. If you’re a science nerd, you might notice the hint at Einstein's formula.
This supplement offers a unique blend of 500 mg of nicotinamide and 100 mg of resveratrol to enhance its effects on cellular health, support healthy aging, and optimize cellular function.
A few of our clients reported a significant change in their energy and sleep patterns upon using this product.
People also like the long-term effects that might reduce some natural aging in the body [1].
Amount:
- Nicotinamide : 500mg
- Resveratrol : 100mg
- Might help boost your energy levels and immune system
- Claims to be a flush-free product to avoid side effects
- Seems to provide healthy aging and anti-inflammatory properties
- Resveratrol is not suitable for people undergoing blood-thinning medication
The important thing to keep in mind with resveratrol is that it’s not suitable for some types of medication.
5 - HPN Nutraceuticals Nicotinamide Riboside
HPN received positive feedback from our reviews, particularly its various forms of nutritional science benefits.
One of my clients reported significant improvement in focus and mental stamina. Other benefits mentioned by our clients include improved physical performance, mental boosts, and an improved immune system.
This NAD booster is designed to improve cellular health by supplying the human body with 311 mg of NAD3 which comprises Wasabia japonica, theacrine, and cuprous niacin, all of which help improve cellular energy metabolism to support a healthy lifestyle.
It also claims to help reduce metabolic disease issues that could often leave you feeling sluggish.
Amount:
- Nicotinamide Riboside : 250 mg
- Seems to be working well for improving mood and brain function
- Claims to enhance your natural metabolism for more effective energy production
- Positive comments about measurable increases in levels of NAD
- The capsules are pretty big and may take getting used to
You might need to get used to the size of the capsules, as they aren’t the easiest to swallow.
6 - Thorne Research ResveraCel
Thorne's products are considered one of the best NAD supplements on the market today and a top choice for older athletes.
As one of the most trusted brands in providing dietary supplements, Thorne Research's ResveraCel is another product where we saw quite a few positive comments online about how it could improve the levels of NAD precursors.
This would explain why quite a few older people seem to show signs of improvement within weeks. Benefits include cognitive function, DNA repair, cellular energy production, and cell metabolism.
With 415 mg of nicotinamide riboside NR, ResveraCel claims to promote healthy aging by targeting the effects from inside and out. It also has added clinically proven ingredients like quercetin phytosome, trans-resveratrol, and betaine anhydrous to increase NR's effectiveness.
Amount:
- Nicotinamide Riboside : 300 mg
- Seems to work well for stabilizing aging effects at the cell level
- Batches go through multiple rounds of testing to ensure quality and purity
- May also support healthy heart and cognitive function
- Gluten, soy, and dairy-free
- The capsules are almost an inch long, making them a bit difficult to swallow
These capsules are possibly the largest we encountered, so keep that in mind before ordering.
7 - MAAC10 NMN
We like that MAAC10 takes consistency and quality seriously. Every batch of this supplement is tested to ensure you always get the right grade and concentration for cellular repair.
The amount of nicotinamide mononucleotide per serving is quite low at 125 mg so you may need to take more than one serving per day, depending on your needs. It's best to consult a licensed healthcare provider first if you plan to take more than the approved dosage.
You also have the option to ask for your money back within 60 days of purchase if you’re not satisfied with the changes it might bring to your life.
Many customers say that MAAC10 NMN supplements improved their physical performance, increased their cellular energy, and gave them better mental clarity within a few weeks of taking it. The product also had mood-boosting effects.
Amount:
- NMN : 125 mg
- Claims to be more stable and effective than nicotinamide riboside
- Tested for 99% purity and higher-grade content
- Comes with a 60-day money-back guarantee for peace of mind
- The dosage is quite low, so may not be as effective as the others
I would say that this isn’t the best option if you’re looking to make a more significant change in your body as the dosage is quite low. Regardless, this healthier aging supplement is a good place to start before fully committing to the lifestyle.
8 - Ultra Health NAD+
Ultra Health NAD+ is among the cheaper NR supplement options available. However, that doesn’t mean it uses inferior ingredients that aren't backed by science.
We saw some blood test results from users that showed an increase in NAD levels after a month of consistent intake.
Clients say they experienced a significant increase in cellular energy production and mental capacity with this supplement. Some also noticed fewer wrinkles on their skin.
Amount:
- Nicotinamide Riboside : 300 mg
- Claims to target cellular level immunity to help with age-related problems
- Test results show it may be effective at triggering NAD precursors
- It’s a cheaper option but still seems to work well
- Requires taking two capsules per day
With 500 mg of NR, it's a 100% vegan-friendly supplement made with microcrystalline and vegetable cellulose.
However, you will need to take two capsules for the full dosage. It could be a problem if you have a tendency to forget taking booster supplements more than once every day.
9 - Toniiq NMN
This NMN (nicotinamide mononucleotide) supplement from Toniiq claims to be one of the stronger options available, which could be a good choice for older people trying to achieve a more significant boost for cognitive function.
Aside from having minimalist packaging, it also boasts a highly purified form of NMN of at least 99% purity which enhances its potency in releasing precursors to your body to produce more NAD.
The product has also been designed to be stable at room temperature, which means you won’t need to keep it in the fridge.
Clients who used Toniiq NMN reported experiencing sustained energy boosts and a sharper mind upon taking it. It's a great product if you're still doing high intensity interval training for muscle growth. The supplement also improved the texture of their skin, giving it a softer and healthier appearance.
Amount:
- NMN : 500 mg
- UltraNMN formula claims to be of the highest grade
- Claims to be shelf-stable, so doesn’t require refrigeration
- It’s an affordable bulk order option
- Requires two capsules daily for the full dose
Just keep in mind that the larger dose will require taking two pills per day, which might not suit people who don’t like swallowing capsule supplements.
10 - Genex Formulas Nicotinamide Riboside
Close to the last of our best recommended NAD boosters is from another company that has kept the formula as simple as possible with only 300 mg of nicotinamide riboside as its main ingredient.
It should support higher NAD levels within about four weeks, which is a bit longer than other products but still a decent time frame for an overall increase.
Customers say this supplement gave them more energy to perform everyday tasks, even with a high fat diet. It also made their hair and nails grow faster and reduced the appearance of sunspots on their skin. Their sleep and focus also improved as well.
Amount:
- Nicotinamide Riboside : 250 mg
- Keeps the formula simple, so you know what you get
- Positive comments about boosted energy levels and mood
- Doesn’t contain allergens and fillers that might cause side effects
- Some reports about missing pills in bottles
We did notice that a few people have complained about the bottles not containing the right number of pills.
11 - Vivalifer NMN Super Nicotinamide Mononucleotide
Vivalifer NMN is probably one of the best NMN products on the market.
Some studies show that the mononucleotide type used in this product might help with getting better sleep [2]. That might have significant rejuvenating benefits within just a few days.
We also saw quite a few comments where people said they had their NAD levels tested and that there was a measured improvement after taking it for several weeks.
Amount:
- Nicotinamide Mononucleotide (NMN) : 500 mg
- Positive comments about boosted NAD+ levels providing more energy
- Free from common allergens and artificial additives
- Seems to support better sleep cycles
- The capsules are not the smallest to swallow
The only thing we found is that the capsules are a bit on the large side.
There’s a complex, two-way relationship between NAD and circadian rhythms, one that influences sleep-wake patterns and other important physiological processes, including metabolism.
- Dr. Michael Breus, Sleep Specialist
12 - NMN Plus
This NMN supplement stood out because the company made it clear that they kept the formula as simple as possible to avoid any use of allergens or fillers. It literally contains 500 mg of nicotinamide mononucleotide only, nothing unnecessary for a healthy diet.
Users have reported that they feel a better mental attitude and improved brain health upon taking this supplement [3].
We also noted that people are saying their sleep patterns have improved. The improved resting habits enhance cognitive health and other bodily functions, resulting in better overall health.
Amount:
- NMN : 300 mg
- Uses a simple formula with no additives or fillers
- Could improve your mood and sleep pattern
- Seems to have positive reviews about the boosted brain function
- Some of the advertised benefits might take more than 30 days to kick in
While most supplements typically need to be stored in low temperatures, this supplement from NMN Plus is completely stable in non-refrigerated temperatures which makes it convenient to use.
We just found that some potential health benefits didn’t show up until consistently using it for about a month.
What is Nicotinamide Adenine Dinucleotide (NAD+)?
Nicotinamide adenine dinucleotide or NAD+ is a coenzyme found in all living cells that play an important role in cellular health, particularly energy metabolism and gene expression.
NAD+ helps cells create more energy so we can have more cells to work for the body, hence better cell function.
Aside from aiding in healthy aging, NAD+ fuels many biological processes like [4}:
- Increasing damaged DNA repair
- Converting food into energy
- Supporting cells' defense systems
- Setting circadian rhythms or internal body clock
However, as we age, our healthy supply of NAD+ declines, and so does our longevity. It becomes pretty easy for our body to develop chronic diseases like heart disease, vision loss, diabetes, and Alzheimer’s disease.
But that's not the only catch. Even other metabolic stressors and neuronal stress can also cause a decline in NAD+ levels and these include lack of physical activity, sleep disturbance, and too much alcohol intake.
As such, NAD+ booster supplements like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) supplements have quickly become an easy and efficient way to effectively increase NAD+ levels.
What's The Difference Between NR and NMN?
Here are the main differences between NR and NMN:
- NR and NMN have roughly similar structures, but NMN has an extra phosphate group which makes it a larger molecule than NR. With this, scientists suggest than NMN is too large to enter cells so it must be first converted to NR.
- NMN is an immediate precursor of NAD+, which means that it directly converts to NAD+ with the help of an enzyme. NR, on the other hand, needs to be converted into NMN first.
While both nicotinamide riboside and nicotinamide mononucleotide are precursors to the essential molecule NAD+, there are small differences between the two that may affect the efficacy and efficiency of conversion to NAD+.
It should also be noted that the body cannot make NAD+ without the amino acid tryptophan. Thus, it's important to take supplements with tryptophan to reap the potential health benefits of NAD+ booster supplements.
So which is better, NR or NMN?
Unfortunately, there is no enough information to answer that question right now, but the good news is that both precursors have been proven to be safe for human use [5]. More research and clinical trials are needed to verify their effects and efficacy.
Benefits of NAD+ Supplements
Promotes Healthy Aging Process
While NAD+ supplements won't reverse time to make you younger, studies show that they can help to counter age-related health conditions like diabetes, vision loss, heart disease, cancer, and arthritis [6].
Helps in Protecting Brain Cells
Since NAD+ helps protect cells from impaired mitochondrial function and oxidative stress, scientists believe that these are linked to the development of age-related brain disorders like Parkinson's and Alzheimer's disease [7].
Aids in Weight Loss
Studies suggest that nicotinamide riboside can help speed up the metabolism of mice by increasing thermogenesis which can result to better weight management [8].
Enhances Muscle Function
While most people use NAD+ supplements for health reasons, some athletes and exercise enthusiasts also take one to improve their physical performance. Studies have linked NAD+ supplements to boost muscle strength, function, and endurance [9].
Side Effects of NAD+ Supplements
NAD+ boosters, both NR and NMN, are generally safe for human use, as several clinical human trials show. A study shows that taking 1,000 to 2,000 mg of nicotinamide riboside per day does not cause adverse side effects [10].
However, other studies reveal that some users may experience mild side effects such as fatigue, nausea, diarrhea, headaches, and indigestion. To prevent these side effects, stick with the recommended dosage of your NAD+ supplement.
From my extensive experience with multiple supplements, I always emphasize reading the label and adhering to the recommended dosage to avoid such side effects.
You must also be discerning when you buy these products since you might be getting fake or expired ones. But before all that, always consult a qualified healthcare provider before making purchases or changing your supplement regimen.
Recommended Dosage
NAD+ supplements are usually in the form of capsule or tablet, like the products mentioned in this review.
Most brands recommend taking 200–500 mg of either nicotinamide riboside or nicotinamide mononucleotide per day which is the equivalent of 1 to 2 capsules.
It's best to consult a doctor first before taking more than the recommended daily dosage of NAD boosters.
FAQs
Is NMN Better Than NAD?
No, NMN isn’t better than NAD, as they are entirely different substances. NMN works as a precursor to NAD, meaning it is converted to NAD with the help of specific enzymes. Studies have shown that taking NMN supplements effectively increases NAD levels in your body and supports healthy aging process. With this, you can expect a considerable life extension.
At What Age Does NAD Decrease?
NAD levels decrease from a young age after puberty. But the most notable reduction comes after age 50 when measured levels might drop as much as 50%. This is why it’s a commonly recommended supplement for older people to support healthy aging process.
What Is the Best Source of NAD?
The best source of NAD includes fish such as tuna, salmon, and sardines. Cow’s milk, mushrooms (especially the crimini), green vegetables (including peas and asparagus), yeast, and whole grains are also excellent sources, making them natural NAD boosters.
How Can I Increase My NAD Naturally?
You can increase NAD naturally by exercising regularly, spending time in heat sources like saunas and hot tubs, limiting sun exposure, eating food items considered as NAD boosters, and adopting intermittent fasting and ketosis.
The Best NAD+ Supplement Is...
All of our testing has made us conclude that Wonderfeel Youngr is the best NAD/NMN supplement you can buy at the moment. It seems to provide the best form for higher absorption, and its success is backed by science.
Our clients have all had positive things to say about it and their performance at the gym and motivation to exercise more have all improved.
You should also try to take advantage of the bulk discounts available, which most other products don’t offer.
And make sure you report back to us how quickly you think it resulted in some improvements for your body.
Our #1 Recommendation
Wonderfeel® Youngr™
- Boosts recovery after long-working days
- It makes aerobic activities much easier
- It has an affordable price
- Get the BEST PRICE until the end of September
- The 900 mg dose may be too much for certain people
About The Author
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I’m actually curious about is how much you should take to avoid making this supplement a replacement for natural NAD+ production or the use of natural stored NAD+, and if there’s a bigger chance of this happening if you start taking it at a young age.
Great delivery. Great arguments. Keep up the amazing spirit.